MESENCHYMAL STEM CELL-DERIVED EXOSOME-EDUCATED MACROPHAGES ALLEVIATE SYSTEMIC LUPUS ERYTHEMATOSUS BY PROMOTING EFFEROCYTOSIS AND RECRUITMENT OF IL-17+ REGULATORY T CELL

Abstract Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE).Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of macrophages.However, the possible therapeutic effect of exosomes from stem cells on SLE remains un

Abstract Background Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes.PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in NB and various other cancers that promote MYCN stabilization.In addition, both the MYCN and mTOR sig

Background and Objectives: Sheeppox virus causes systemic disease in sheep that is often associated with high morbidity and mortality.Protection against sheep pox is mainly based on medical prophylaxis, vaccination being the only way.In Morocco, and up to now, there is no available information about local challenge strain to use for controlling the